dmwi228

BSc Pharmacology, Cardiff University, United Kingdom
PhD Medical Sciences (Pharmacology), University of South Florida, Tampa, FL
Postdoctoral fellow, Albert Einstein College of Medicine, Bronx, NY
Postdoctoral fellow, Duke University, Durham, NC

Research Description:

The Wilcock lab is interested in vascular cognitive impairment and dementia; the second most common cause of dementia behind Alzheimer's disease. In addition to being a major cause of dementia, Alzheimer's disease patients commonly have vascular cognitive impairment as a co-morbidity. We have projects to examine the molecular mechanisms of vascular cognitive impairment, focusing primarily on inflammatory processes. We also have projects that determine the influence cerebrovascular disease has on the progression and severity of Alzheimer's disease, as well as how these vascular pathologies affects response to Alzheimer's disease targeted therapeutics. Finally, we have a project in collaboration with Elizabeth Head of Pharmacology and Frederick Schmitt of Neurology to assess neuroinflammatory changes in Down Syndrome. We are developing a translational research program examining neuroinflammatory proteins and homocysteine as modifiable biomarkers of cognitive impairment due to both Alzheimer's disease and cerebrovascular pathologies.

Grants:

2R01 HD064993 Head/Schmitt (MPI) Aging and Dementia in Down syndrome: Connectivity, Inflammation and Cerebrovascular Contributions
The study will identify new ways in which to detect Alzheimer disease (AD) in adults with Down syndrome (DS) by monitoring changes in cognitive function, measuring brain changes by magnetic resonance imaging and profiling patterns of proteins in the plasma. In parallel, autopsy studies of brain samples will help us to understand how noninvasive cognitive, imaging and blood measures reflect the development of AD in DS.

1R01NS079637 - Vascular breakdown in Alzheimer’s Disease with cerebrovascular disease.
This is a grant to study the co-morbidity of vascular dementia and Alzheimer’s disease focusing on the neuroinflammatory mechanisms of both dementias and the therapeutic efficacy of targeting one dementia as opposed to the other.

DSDNIP-13-282631 - Inflammatory biomarkers to predict transition to dementia in Down Syndrome
A grant to study changes in inflammatory biomarkers in the plasma on Down Syndrome patients at risk of transitioning to dementia. We will look at markers pre and post transition to establish potential predictive biomarkers.

PubMed Publications:

Muratoglu, SC ; Charette, MF ; Galis, ZS ; Greenstein, AS ; Daugherty, A.; Joutel, A ; Kozel, BA ; Wilcock, DM ; Collins, EC ; Sorond, FA ; Howell, GR ; Hyacinth, HI ; Lloyd, KKC ; Stenmark, KR ; Boehm, M.; Kahn, ML ; Corriveau, R ; Wells, S.; Bussey, TJ ; Rizzo, SJ Sukoff; Iruela-Arispe, ML "Perspectives on Cognitive Phenotypes and Models of Vascular Disease." Arteriosclerosis, thrombosis, and vascular biology (2022): 101161ATVBAHA122317395. [PubMed Link] | [ Full text ]
Seaks, CE ; Weekman, EM ; Sudduth, TL ; Xie, K.; Wasek, B ; Fardo, DW ; Johnson, LA ; Bottiglieri, T ; Wilcock, DM "Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 42, 5 (2022): 771-787. [PubMed Link] | [ Full text ]
Wilcock, DM ; McMurtry, V ; Coleman, JF ; Kim, JT ; Khalili, P ; Deftereos, G ; Albertson, D ; Gulbahce, EH ; Liu, T.; Sirohi, D "Histopathological Correlation of Chromosome 12 Polysomy by Fluorescence in Situ Hybridization in Adipocytic Neoplasms." International journal of surgical pathology (2022): 10668969221085289. [PubMed Link] | [ Full text ]
Winder, Z ; Sudduth, TL ; Anderson, S.; Patel, E.; Neltner, J.; Martin, BJ ; Snyder, KE ; Abner, EL ; Jicha, GA ; Nelson, PT ; Wilcock, DM "Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort." Alzheimer's & dementia : the journal of the Alzheimer's Association (2022): [PubMed Link] | [ Full text ]
Gal, J.; Katsumata, Y.; Zhu, H.; Srinivasan, S.; Chen, J.; Johnson, LA ; Wang, WX ; Golden, LR ; Wilcock, DM ; Jicha, GA ; Cykowski, MD ; Nelson, PT "Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele." The American journal of pathology 192, 3 (2022): 564-578. [PubMed Link] | [ Full text ]
Wilcock, DM ; Schmidt, RL ; Furtado, LV ; Matynia, AP ; Deftereos, G ; Sirohi, D "Histologic and Molecular Characterization of Non-Small Cell Lung Carcinoma With Discordant ROS1 Immunohistochemistry and Fluorescence In Situ Hybridization." Applied immunohistochemistry & molecular morphology : AIMM 30, 1 (2022): 19-26. [PubMed Link] | [ Full text ]
Whitehead, SN ; Bruno, A ; Burns, JM ; Carmichael, ST ; Csiszar, A.; Edwards, JD ; Elahi, FM ; Faraco, G.; Gould, DB ; Gustafson, DR ; Hachinski, V ; Rosenberg, G ; Sorond, FA ; Shih, AY ; Tse, KH ; Ungvari, Z.; Wilcock, DM ; Zuloaga, KL ; Barone, FC "Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition." GeroScience 44, 1 (2022): 25-37. [PubMed Link] | [ Full text ]
Kloske, CM ; Dugan, AJ ; Weekman, EM ; Winder, Z ; Patel, E.; Nelson, PT ; Fardo, DW ; Wilcock, DM "Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status." Journal of neuropathology and experimental neurology 80, 10 (2021): 922-932. [PubMed Link] | [ Full text ]
Pajewski, NM ; Elahi, FM ; Tamura, MK ; Hinman, JD ; Nasrallah, IM ; Ix, JH ; Miller, LM ; Launer, LJ ; Wright, CB ; Supiano, MA ; Lerner, AJ ; Sudduth, TL ; Killeen, AA ; Cheung, AK ; Reboussin, DM ; Wilcock, DM ; Williamson, JD "Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT)." Alzheimer's & dementia : the journal of the Alzheimer's Association (2021): [PubMed Link] | [ Full text ]
Selvaraj, UM ; Ujas, TA ; Kong, X.; Kumar, A.; Plautz, EJ ; Zhang, S.; Xing, C ; Sudduth, TL ; Wilcock, DM ; Turchan-Cholewo, J.; Goldberg, MP ; Stowe, AM "Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice." Brain, behavior, and immunity 95, (2021): 502-513. [PubMed Link] | [ Full text ]
Blevins, BL ; Vinters, HV ; Love, S.; Wilcock, DM ; Grinberg, LT ; Schneider, JA ; Kalaria, RN ; Katsumata, Y.; Gold, BT ; Wang, DJJ ; Ma, SJ ; Shade, LMP ; Fardo, DW ; Hartz, AMS ; Jicha, GA ; Nelson, KB ; Magaki, SD ; Schmitt, FA ; Teylan, MA ; Ighodaro, ET ; Phe, P ; Abner, EL ; Cykowski, MD ; Van Eldik, LJ ; Nelson, PT "Brain arteriolosclerosis." Acta neuropathologica 141, 1 (2021): 1-24. [PubMed Link] | [ Full text ]
Gold, BT ; Shao, X.; Sudduth, TL ; Jicha, GA ; Wilcock, DM ; Seago, ER ; Wang, DJJ "Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults." Alzheimer's & dementia : the journal of the Alzheimer's Association 17, 12 (2021): 2020-2029. [PubMed Link] | [ Full text ]
Bahrani, AA ; Smith, CD ; Barber, JM ; Al-Janabi, OM ; Powell, DK ; Andersen, AH ; Ramey, BD ; Abner, EL ; Goldstein, LB ; Winder, Z ; Gold, BT ; Van Eldik, L.; Wilcock, DM ; Jicha, GA "Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia." Journal of neuroscience methods 360, (2021): 109270. [PubMed Link] | [ Full text ]
Ly, H.; Verma, N.; Sharma, S.; Kotiya, D ; Despa, S.; Abner, EL ; Nelson, PT ; Jicha, GA ; Wilcock, DM ; Goldstein, LB ; Guerreiro, R.; Bras, J.; Hanson, AJ ; Craft, S.; Murray, AJ ; Biessels, GJ ; Troakes, C ; Zetterberg, H.; Hardy, J.; Lashley, T ; , ; Despa, F. "The association of circulating amylin with β-amyloid in familial Alzheimer's disease." Alzheimer's & dementia (New York, N. Y.) 7, 1 (2021): e12130. [PubMed Link] |
Seaks, CE ; Wilcock, DM "Infectious hypothesis of Alzheimer disease." PLoS pathogens 16, 11 (2020): e1008596. [PubMed Link] | [ Full text ]
Toden, S ; Zhuang, J.; Acosta, AD ; Karns, AP ; Salathia, NS ; Brewer, JB ; Wilcock, DM ; Aballi, J ; Nerenberg, M ; , ; Ibarra, A. "Noninvasive characterization of Alzheimer's disease by circulating, cell-free messenger RNA next-generation sequencing." Science advances 6, 50 (2020): [PubMed Link] | [ Full text ]
Price, BR ; Sudduth, TL ; Weekman, EM ; Johnson, S.; Hawthorne, D ; Woolums, A.; Wilcock, DM "Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition." Journal of neuroinflammation 17, 1 (2020): 238. [PubMed Link] | [ Full text ]
Winder, Z ; Sudduth, TL ; Fardo, D ; Cheng, Q.; Goldstein, LB ; Nelson, PT ; Schmitt, FA ; Jicha, GA ; Wilcock, DM "Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers." Frontiers in neuroscience 14, (2020): 84. [PubMed Link] | [ Full text ]
Kloske, CM ; Wilcock, DM "The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease." Frontiers in immunology 11, (2020): 754. [PubMed Link] | [ Full text ]
Braun, DJ ; Bachstetter, AD ; Sudduth, TL ; Wilcock, DM ; Watterson, DM ; Van Eldik, LJ "Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia." GeroScience 41, 5 (2019): 671-679. [PubMed Link] | [ Full text ]
Bahrani, AA ; Al-Janabi, OM ; Abner, EL ; Bardach, SH ; Kryscio, RJ ; Wilcock, DM ; Smith, CD ; Jicha, GA "Post-acquisition processing confounds in brain volumetric quantification of white matter hyperintensities." Journal of neuroscience methods 327, (2019): 108391. [PubMed Link] | [ Full text ]
Al-Janabi, OM ; Bauer, CE ; Goldstein, LB ; Murphy, RR ; Bahrani, AA ; Smith, CD ; Wilcock, DM ; Gold, BT ; Jicha, GA "White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups." Brain sciences 9, 7 (2019): [PubMed Link] | [ Full text ]
Braun, DJ ; Abner, E.; Bakshi, V.; Goulding, DS ; Grau, EM ; Lin, AL ; Norris, CM ; Sudduth, TL ; Webster, SJ ; Wilcock, DM ; Van Eldik, LJ "Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia." ASN neuro 11, (2019): 1759091419865788. [PubMed Link] | [ Full text ]
Lourenco, MV ; Frozza, RL ; de Freitas, GB ; Zhang, H.; Kincheski, GC ; Ribeiro, FC ; Gonçalves, RA ; , ; Beckman, D ; Staniszewski, A.; Berman, H ; Guerra, LA ; Forny-Germano, L ; Meier, S.; Wilcock, DM ; de Souza, JM ; Alves-Leon, S ; Prado, VF ; Prado, MAM ; Abisambra, JF ; Tovar-Moll, F ; Mattos, P ; Arancio, O.; Ferreira, ST ; De Felice, FG "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models." Nature medicine 25, 1 (2019): 165-175. [PubMed Link] | [ Full text ]
Babulal, GM ; Quiroz, YT ; Albensi, BC ; Arenaza-Urquijo, E ; Astell, AJ ; Babiloni, C ; Bahar-Fuchs, A ; Bell, J ; Bowman, GL ; Brickman, AM ; Chételat, G ; Ciro, C ; Cohen, AD ; Dilworth-Anderson, P ; Dodge, HH ; Dreux, S ; Edland, S ; Esbensen, A ; Evered, L ; Ewers, M ; Fargo, KN ; Fortea, J.; Gonzalez, H ; Gustafson, DR ; Head, E.; Hendrix, JA ; Hofer, SM ; Johnson, LA ; Jutten, R ; Kilborn, K ; Lanctôt, KL ; Manly, JJ ; Martins, RN ; Mielke, MM ; Morris, MC ; Murray, ME ; Oh, ES ; Parra, MA ; Rissman, RA ; Roe, CM ; Santos, OA ; Scarmeas, N ; Schneider, LS ; Schupf, N.; Sikkes, S ; Snyder, HM ; Sohrabi, HR ; Stern, Y ; Strydom, A ; Tang, Y.; Terrera, GM ; Teunissen, C ; van Lent, Melo ; Weinborn, M ; Wesselman, L ; Wilcock, DM ; Zetterberg, H.; O'Bryant, SE ; , "Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need." Alzheimer's & dementia : the journal of the Alzheimer's Association 15, 2 (2019): 292-312. [PubMed Link] | [ Full text ]
Weekman, EM ; Sudduth, TL ; Price, BR ; Woolums, AE ; Hawthorne, D ; Seaks, CE ; Wilcock, DM "Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events." Journal of neuroinflammation 16, 1 (2019): 284. [PubMed Link] | [ Full text ]
Aldea, R ; Weller, RO ; Wilcock, DM ; Carare, RO ; Richardson, G "Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain." Frontiers in aging neuroscience 11, (2019): 1. [PubMed Link] | [ Full text ]
Alber, J ; Alladi, S ; Bae, HJ ; Barton, DA ; Beckett, LA ; Bell, JM ; Berman, SE ; Biessels, GJ ; Black, SE ; Bos, I ; Bowman, GL ; Brai, E ; Brickman, AM ; Callahan, BL ; Corriveau, RA ; Fossati, S ; Gottesman, RF ; Gustafson, DR ; Hachinski, V ; Hayden, KM ; Helman, AM ; Hughes, TM ; Isaacs, JD ; Jefferson, AL ; Johnson, SC ; Kapasi, A ; Kern, S.; Kwon, JC ; Kukolja, J ; Lee, A.; Lockhart, SN ; Murray, A.; Osborn, KE ; Power, MC ; Price, BR ; Rhodius-Meester, HFM ; Rondeau, JA ; Rosen, AC ; Rosene, DL ; Schneider, JA ; Scholtzova, H ; Shaaban, CE ; Silva, NCBS ; Snyder, HM ; Swardfager, W ; Troen, AM ; van Veluw, SJ ; Vemuri, P.; Wallin, A.; Wellington, C.; Wilcock, DM ; Xie, SX ; Hainsworth, AH "White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities." Alzheimer's & dementia (New York, N. Y.) 5, (2019): 107-117. [PubMed Link] |
Al-Janabi, OM ; Panuganti, P.; Abner, EL ; Bahrani, AA ; Murphy, R.; Bardach, SH ; Caban-Holt, A.; Nelson, PT ; Gold, BT ; Smith, CD ; Wilcock, DM ; Jicha, GA "Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities." Journal of neuroimaging : official journal of the American Society of Neuroimaging 28, 3 (2018): 301-306. [PubMed Link] | [ Full text ]
Price, BR ; Norris, CM ; Sompol, P.; Wilcock, DM "An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia." Journal of neurochemistry 144, 5 (2018): 644-650. [PubMed Link] | [ Full text ]
Nelson, PT ; Abner, EL ; Patel, E.; Anderson, S.; Wilcock, DM ; Kryscio, RJ ; Van Eldik, LJ ; Jicha, GA ; Gal, Z.; Nelson, RS ; Nelson, BG ; Gal, J.; Azam, MT ; Fardo, DW ; Cykowski, MD "The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases." Journal of neuropathology and experimental neurology 77, 1 (2018): 2-20. [PubMed Link] | [ Full text ]
Abner, EL ; Neltner, JH ; Jicha, GA ; Patel, E.; Anderson, SL ; Wilcock, DM ; Van Eldik, LJ ; Nelson, PT "Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques." Journal of Alzheimer's disease : JAD 64, 4 (2018): 1307-1324. [PubMed Link] | [ Full text ]
Al-Janabi, OM ; Brown, CA ; Bahrani, AA ; Abner, EL ; Barber, JM ; Gold, BT ; Goldstein, LB ; Murphy, RR ; Nelson, PT ; Johnson, NF ; Shaw, LM ; Smith, CD ; Trojanowski, JQ ; Wilcock, DM ; Jicha, GA "Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension." Journal of Alzheimer's disease : JAD 66, 3 (2018): 1095-1104. [PubMed Link] | [ Full text ]
Price, BR ; Wilcock, DM ; Weekman, EM "Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia." Frontiers in aging neuroscience 10, (2018): 350. [PubMed Link] | [ Full text ]
Weekman, EM ; Woolums, AE ; Sudduth, TL ; Wilcock, DM "Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain." ASN neuro 9, 6 (2017): 1759091417742296. [PubMed Link] | [ Full text ]
Sudduth, TL ; Weekman, EM ; Price, BR ; Gooch, JL ; Woolums, A.; Norris, CM ; Wilcock, DM "Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)." Neuroscience 341, (2017): 42-51. [PubMed Link] | [ Full text ]
Davis, PR ; Giannini, G.; Rudolph, K.; Calloway, N.; Royer, CM ; Beckett, TL ; Murphy, MP ; Bresch, F.; Pagani, D.; Platt, T.; Wang, X.; Donovan, AS ; Sudduth, TL ; Lou, W.; Abner, E.; Kryscio, R.; Wilcock, DM ; Barrett, EG ; Head, E. "Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages." Neurobiology of aging 49, (2017): 86-99. [PubMed Link] | [ Full text ]
Weekman, EM ; Sudduth, TL ; Caverly, CN ; Kopper, TJ ; Phillips, OW ; Powell, DK ; Wilcock, DM "Reduced Efficacy of Anti-Aβ Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity." The Journal of neuroscience : the official journal of the Society for Neuroscience 36, 38 (2016): 9896-907. [PubMed Link] | [ Full text ]
Pleiss, MM ; Sompol, P.; Kraner, SD ; Abdul, HM ; Furman, JL ; Guttmann, RP ; Wilcock, DM ; Nelson, PT ; Norris, CM "Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function." Biochimica et biophysica acta 1862, 9 (2016): 1521-32. [PubMed Link] | [ Full text ]
Wilcock, DM ; Schmitt, FA ; Head, E. "Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome." Biochimica et biophysica acta 1862, 5 (2016): 909-14. [PubMed Link] | [ Full text ]
Hainsworth, AH ; Yeo, NE ; Weekman, EM ; Wilcock, DM "Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)." Biochimica et biophysica acta 1862, 5 (2016): 1008-17. [PubMed Link] | [ Full text ]
Murphy, MP ; Corriveau, RA ; Wilcock, DM "Vascular contributions to cognitive impairment and dementia (VCID)." Biochimica et biophysica acta 1862, 5 (2016): 857-9. [PubMed Link] | [ Full text ]
Gooch, J.; Wilcock, DM "Animal Models of Vascular Cognitive Impairment and Dementia (VCID)." Cellular and molecular neurobiology 36, 2 (2016): 233-9. [PubMed Link] | [ Full text ]
Van Eldik, LJ ; Carrillo, MC ; Cole, PE ; Feuerbach, D.; Greenberg, BD ; Hendrix, JA ; Kennedy, M.; Kozauer, N.; Margolin, RA ; Molinuevo, JL ; Mueller, R.; Ransohoff, RM ; Wilcock, DM ; Bain, L.; Bales, K. "The roles of inflammation and immune mechanisms in Alzheimer's disease." Alzheimer's & dementia (New York, N. Y.) 2, 2 (2016): 99-109. [PubMed Link] |
Madigan, JB ; Wilcock, DM ; Hainsworth, AH "Vascular Contributions to Cognitive Impairment and Dementia: Topical Review of Animal Models." Stroke 47, 7 (2016): 1953-9. [PubMed Link] | [ Full text ]
Martins, TB ; Bandhauer, ME ; Wilcock, DM ; Hill, HR ; Slev, PR "Specific Immunoglobulin (Ig) G Reference Intervals for Common Food, Insect, and Mold Allergens." Annals of clinical and laboratory science 46, 6 (2016): 635-638. [PubMed Link] | [ Full text ]
Weekman, EM ; Wilcock, DM "Matrix Metalloproteinase in Blood-Brain Barrier Breakdown in Dementia." Journal of Alzheimer's disease : JAD 49, 4 (2016): 893-903. [PubMed Link] | [ Full text ]
Head, E.; Lott, IT ; Wilcock, DM ; Lemere, CA "Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology." Current Alzheimer research 13, 1 (2016): 18-29. [PubMed Link] | [ Full text ]
Lin, AL ; Powell, D.; Caban-Holt, A.; Jicha, G.; Robertson, W.; Gold, BT ; Davis, R.; Abner, E.; Wilcock, DM ; Schmitt, FA ; Head, E. "(1)H-MRS metabolites in adults with Down syndrome: Effects of dementia." NeuroImage. Clinical 11, (2016): 728-735. [PubMed Link] | [ Full text ]
Wilcock, DM ; Hurban, J.; Helman, AM ; Sudduth, TL ; McCarty, KL ; Beckett, TL ; Ferrell, JC ; Murphy, MP ; Abner, EL ; Schmitt, FA ; Head, E. "Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease." Neurobiology of aging 36, 9 (2015): 2468-74. [PubMed Link] | [ Full text ]
Latta, CH ; Sudduth, TL ; Weekman, EM ; Brothers, HM ; Abner, EL ; Popa, GJ ; Mendenhall, MD ; Gonzalez-Oregon, F.; Braun, K.; Wilcock, DM "Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice." Journal of neuroinflammation 12, (2015): 41. [PubMed Link] | [ Full text ]
Snyder, HM ; Corriveau, RA ; Craft, S.; Faber, JE ; Greenberg, SM ; Knopman, D.; Lamb, BT ; Montine, TJ ; Nedergaard, M.; Schaffer, CB ; Schneider, JA ; Wellington, C.; Wilcock, DM ; Zipfel, GJ ; Zlokovic, B.; Bain, LJ ; Bosetti, F.; Galis, ZS ; Koroshetz, W.; Carrillo, MC "Vascular contributions to cognitive impairment and dementia including Alzheimer's disease." Alzheimer's & dementia : the journal of the Alzheimer's Association 11, 6 (2015): 710-7. [PubMed Link] | [ Full text ]
Latta, CH ; Sudduth, TL ; Weekman, EM ; Brothers, HM ; Abner, EL ; Popa, GJ ; Mendenhall, MD ; Gonzalez-Oregon, F.; Braun, K.; Wilcock, DM "Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice." Journal of neuroinflammation 12, 1 (2015): 243. [PubMed Link] | [ Full text ]
Latta, CH ; Brothers, HM ; Wilcock, DM "Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy." Neuroscience 302, (2015): 103-11. [PubMed Link] | [ Full text ]
Niedowicz, DM ; Reeves, VL ; Platt, TL ; Kohler, K.; Beckett, TL ; Powell, DK ; Lee, TL ; Sexton, TR ; Song, ES ; Brewer, LD ; Latimer, CS ; Kraner, SD ; Larson, KL ; Ozcan, S.; Norris, CM ; Hersh, LB ; Porter, NM ; Wilcock, DM ; Murphy, MP "Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia." Acta neuropathologica communications 2, (2014): 64. [PubMed Link] | [ Full text ]
Weekman, EM ; Sudduth, TL ; Abner, EL ; Popa, GJ ; Mendenhall, MD ; Brothers, HM ; Braun, K.; Greenstein, A.; Wilcock, DM "Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice." Journal of neuroinflammation 11, (2014): 127. [PubMed Link] | [ Full text ]
Colton, CA ; Wilson, JG ; Everhart, A.; Wilcock, DM ; Puoliväli, J.; Heikkinen, T.; Oksman, J.; Jääskeläinen, O.; Lehtimäki, K.; Laitinen, T.; Vartiainen, N.; Vitek, MP "mNos2 deletion and human NOS2 replacement in Alzheimer disease models." Journal of neuropathology and experimental neurology 73, 8 (2014): 752-69. [PubMed Link] | [ Full text ]
Wilcock, DM "Neuroinflammatory phenotypes and their roles in Alzheimer's disease." Neuro-degenerative diseases 13, 2-3 (2014): 183-5. [PubMed Link] | [ Full text ]
Sudduth, TL ; Weekman, EM ; Brothers, HM ; Braun, K.; Wilcock, DM "β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice." Alzheimer's research & therapy 6, 3 (2014): 32. [PubMed Link] | [ Full text ]
Sudduth, TL ; Powell, DK ; Smith, CD ; Greenstein, A.; Wilcock, DM "Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 33, 5 (2013): 708-15. [PubMed Link] | [ Full text ]
Sudduth, TL ; Greenstein, A.; Wilcock, DM "Intracranial injection of Gammagard, a human IVIg, modulates the inflammatory response of the brain and lowers Aβ in APP/PS1 mice along a different time course than anti-Aβ antibodies." The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 23 (2013): 9684-92. [PubMed Link] | [ Full text ]
Wilcock, DM ; Griffin, WS "Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis." Journal of neuroinflammation 10, (2013): 84. [PubMed Link] | [ Full text ]
Nelson, PT ; Pious, NM ; Jicha, GA ; Wilcock, DM ; Fardo, DW ; Estus, S.; Rebeck, GW "APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature." Journal of neuropathology and experimental neurology 72, 7 (2013): 708-15. [PubMed Link] | [ Full text ]
Sudduth, TL ; Schmitt, FA ; Nelson, PT ; Wilcock, DM "Neuroinflammatory phenotype in early Alzheimer's disease." Neurobiology of aging 34, 4 (2013): 1051-9. [PubMed Link] | [ Full text ]
Brothers, HM ; Wilcock, DM "Are inflammatory profiles the key to personalized Alzheimer's treatment?" Neurodegenerative disease management 3, 4 (2013): 343-351. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Norris, CM ; Sompol, P.; Wilcock, DM ; Goulding, D.; Neltner, JH ; St Clair, D.; Watterson, DM ; Van Eldik, LJ "Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 30 (2012): 10201-10. [PubMed Link] | [ Full text ]
Ridnour, LA ; Dhanapal, S.; Hoos, M.; Wilson, J.; Lee, J.; Cheng, RY ; Brueggemann, EE ; Hines, HB ; Wilcock, DM ; Vitek, MP ; Wink, DA ; Colton, CA "Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1." Journal of neurochemistry 123, 5 (2012): 736-49. [PubMed Link] | [ Full text ]
Wilcock, DM "A changing perspective on the role of neuroinflammation in Alzheimer's disease." International journal of Alzheimer's disease 2012, (2012): 495243. [PubMed Link] | [ Full text ]
Wilcock, DM "Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease." Current gerontology and geriatrics research 2012, (2012): 170276. [PubMed Link] | [ Full text ]
Sudduth, TL ; Wilson, JG ; Everhart, A.; Colton, CA ; Wilcock, DM "Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype." PloS one 7, 2 (2012): e31993. [PubMed Link] | [ Full text ]
Wilcock, DM ; Morgan, D.; Gordon, MN ; Taylor, TL ; Ridnour, LA ; Wink, DA ; Colton, CA "Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence." Journal of neuroinflammation 8, (2011): 115. [PubMed Link] | [ Full text ]
Wilcock, DM ; Zhao, Q.; Morgan, D.; Gordon, MN ; Everhart, A.; Wilson, JG ; Lee, JE ; Colton, CA "Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses." ASN neuro 3, 5 (2011): 249-58. [PubMed Link] | [ Full text ]
Dawson, HN ; Cantillana, V.; Jansen, M.; Wang, H.; Vitek, MP ; Wilcock, DM ; Lynch, JR ; Laskowitz, DT "Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease." Neuroscience 169, 1 (2010): 516-31. [PubMed Link] | [ Full text ]
Wilcock, DM "The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease." CNS & neurological disorders drug targets 9, 4 (2010): 386-94. [PubMed Link] |
Colton, C.; Wilcock, DM "Assessing activation states in microglia." CNS & neurological disorders drug targets 9, 2 (2010): 174-91. [PubMed Link] |
Wilcock, DM ; Vitek, MP ; Colton, CA "Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease." Neuroscience 159, 3 (2009): 1055-69. [PubMed Link] | [ Full text ]
Wilcock, DM ; Colton, CA "Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice." CNS & neurological disorders drug targets 8, 1 (2009): 50-64. [PubMed Link] |
Wilcock, DM ; Gharkholonarehe, N.; Van Nostrand, WE ; Davis, J.; Vitek, MP ; Colton, CA "Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 25 (2009): 7957-65. [PubMed Link] | [ Full text ]
Wilcock, DM ; Lewis, MR ; Van Nostrand, WE ; Davis, J.; Previti, ML ; Gharkholonarehe, N.; Vitek, MP ; Colton, CA "Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2." The Journal of neuroscience : the official journal of the Society for Neuroscience 28, 7 (2008): 1537-45. [PubMed Link] | [ Full text ]
Colton, CA ; Wilcock, DM ; Wink, DA ; Davis, J.; Van Nostrand, WE ; Vitek, MP "The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP." Journal of Alzheimer's disease : JAD 15, 4 (2008): 571-87. [PubMed Link] | [ Full text ]
Wilcock, DM ; Colton, CA "Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials." Journal of Alzheimer's disease : JAD 15, 4 (2008): 555-69. [PubMed Link] | [ Full text ]
Wilcock, DM ; Jantzen, PT ; Li, Q.; Morgan, D.; Gordon, MN "Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid." Neuroscience 144, 3 (2007): 950-60. [PubMed Link] | [ Full text ]
Wilcock, DM ; Alamed, J.; Gottschall, PE ; Grimm, J.; Rosenthal, A.; Pons, J.; Ronan, V.; Symmonds, K.; Gordon, MN ; Morgan, D. "Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice." The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 20 (2006): 5340-6. [PubMed Link] | [ Full text ]
Carty, NC ; Wilcock, DM ; Rosenthal, A.; Grimm, J.; Pons, J.; Ronan, V.; Gottschall, PE ; Gordon, MN ; Morgan, D. "Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice." Journal of neuroinflammation 3, (2006): 11. [PubMed Link] | [ Full text ]
Alamed, J.; Wilcock, DM ; Diamond, DM ; Gordon, MN ; Morgan, D. "Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice." Nature protocols 1, 4 (2006): 1671-9. [PubMed Link] | [ Full text ]
Wilcock, DM ; Gordon, MN ; Morgan, D. "Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain." Nature protocols 1, 3 (2006): 1591-5. [PubMed Link] | [ Full text ]
Dickey, CA ; Gordon, MN ; Wilcock, DM ; Herber, DL ; Freeman, MJ ; Morgan, D. "Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice." BMC neuroscience 6, (2005): 7. [PubMed Link] | [ Full text ]
Wilcock, DM ; Rojiani, A.; Rosenthal, A.; Levkowitz, G.; Subbarao, S.; Alamed, J.; Wilson, D.; Wilson, N.; Freeman, MJ ; Gordon, MN ; Morgan, D. "Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition." The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 27 (2004): 6144-51. [PubMed Link] | [ Full text ]
Wilcock, DM ; Munireddy, SK ; Rosenthal, A.; Ugen, KE ; Gordon, MN ; Morgan, D. "Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration." Neurobiology of disease 15, 1 (2004): 11-20. [PubMed Link] | [ Full text ]
Wilcock, DM ; Rojiani, A.; Rosenthal, A.; Subbarao, S.; Freeman, MJ ; Gordon, MN ; Morgan, D. "Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage." Journal of neuroinflammation 1, 1 (2004): 24. [PubMed Link] | [ Full text ]
Wilcock, DM ; DiCarlo, G.; Henderson, D.; Jackson, J.; Clarke, K.; Ugen, KE ; Gordon, MN ; Morgan, D. "Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation." The Journal of neuroscience : the official journal of the Society for Neuroscience 23, 9 (2003): 3745-51. [PubMed Link] | [ Full text ]
Wilcock, DM ; Gordon, MN ; Ugen, KE ; Gottschall, PE ; DiCarlo, G.; Dickey, C.; Boyett, KW ; Jantzen, PT ; Connor, KE ; Melachrino, J.; Hardy, J.; Morgan, D. "Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels." DNA and cell biology 20, 11 (2001): 731-6. [PubMed Link] | [ Full text ]